New findings may aid engineering of tooth enamel
Scientists have identified the way a simple amino acid makes human teeth strong and resilient.
Proline is repeated in the centre of proteins found in tooth enamel.
When the repeats are long, such as in humans, they contract groups of molecules that help enamel crystals grow. When the repeats are short, such as in frogs, teeth don’t have the enamel prisms that provide strength, the researchers explained.
The research offers clues on how to engineer tooth enamel.
Lead researcher Tom Diekwisch, professor and head of oral biology at the University of Illinois at Chicago College of Dentistry, said: ‘We hope that one day, these findings will help people replace lost parts of the tooth with a healthy layer of new enamel.’
But the benefits may extend well beyond teeth.
He added: ‘Proline repeats are amazing. They hold the key to understanding the structure and function of many natural proteins, including mucins, antifreeze proteins, Alzheimer’s amyloid and prion proteins. We hope that our findings will help many other important areas of scientific research, including the treatment of neurodegenerative diseases.’
The findings are published in the online edition of the journal PLoS Biology.
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